CHRONIC MYELOID-LEUKEMIA PRESENTING ALL-TYPE BCR ABL TRANSCRIPT/

We investigated the breakpoints of the bcr gene in 46 Ph1-positive CML cases by Southern blot analysis of bet rearrangement, and in 17 CML c ases by a combination of Southern blot analysis and RT-PCR. By Souther n blot, the breakpoint was not identified on M-bcr in three CML cases, of which one case showed the P210-type bcr/abl transcript and two cas es showed the ALL-type (P190-type) bcr/abl transcript with or without P210 transcript. Later two cases showed unique hematological profiles such as thrombocytosis, mild myelofibrosis, and relative resistance to alkylating agents. Therefore, the present study suggests that express ion of the P190-type transcript may affect clinical and hematological findings in CML.