SEROLOGICAL PANCREATIC TUMOR-MARKERS AND THE MUC1 APOMUCIN

Over 80% of adenocarcinomas of the pancreas originate from duct cells, which are the major source of mucins in the pancreas. Pathological co nditions produce changes in the composition and structure of the oligo saccharides of colonic and pancreatic mucins, and it has been suggeste d that mucins may have a role in the detection of pancreatic cancer. M ucins are now the targets of a number of immunodiagnostic assays for c ancer, and their possible use in therapy is being studied. This review describes the structure, biosynthesis, and release of mucins, as well as some of their therapeutic applications. The MUC1 type of mucin is emphasized because it is the main type present in bath normal and mali gnant pancreas and because it is associated with several of the serolo gical pancreatic cancer carbohydrate markers, including CA19-9.