PLACENTAL VASCULAR MALFORMATION WITH MESENCHYMAL HYPERPLASIA AND A LOCALIZED CHORIOANGIOMA

We here report a case of placental vascular malformation with mesenchy mal hyperplasia of the villi and a localized chorioangioma. After an u neventful pregnancy our delivered a non-malformed live female infant. The placenta was grossly enlarged, and macroscopically it was characte rized by strongly enlarged varicous chorionic vessels. On the maternal plate vesicle-like structures, giving the impression of partial mole, were seen. At microscopy level, areas of normal looking tissue altern ated with areas of excessively enlarged villi, in which the ground sub stance contained large amounts of acid mucopolysaccharide, correspondi ng to ''mesenchymal hyperplasia''. Moreover, a localized chorioangioma was found. In none of the histological sections were cisterns, abnorm al trophoblastic proliferation, stunted ramification or stromal tropho blastic inclusions observed. In week 15 maternal se-AFP was elevated t o 3.03 multiples of the median. Genetic analysis revealed a normal fem ale karyotype and biparental genomic contributions to a winked loci. P lacental vascular malformation with mesenchymal hyperplasia is differe nt diagnosis to partial mole should be considered placental enlarge is observed along with living fetus.