CHARACTERIZATION OF TALC SAMPLES FROM DIFFERENT SOURCES

Authors
Citation
Kw. Lin et Ge. Peck, CHARACTERIZATION OF TALC SAMPLES FROM DIFFERENT SOURCES, Drug development and industrial pharmacy, 20(19), 1994, pp. 2993-3003
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03639045
Volume
20
Issue
19
Year of publication
1994
Pages
2993 - 3003
Database
ISI
SICI code
0363-9045(1994)20:19<2993:COTSFD>2.0.ZU;2-N
Abstract
Nine different kinds of U.S.P. grade talc Samples were examined for va riations in density, particle size, surface area, tendency of preferre d orientation, and maximum ejection force. It was found that U.S.P. gr ade talcs varied in physical properties. The relationships between var ious physical properties of talc were analyzed using the Pearson's cor relation of coefficient. The results suggested that the talc sample wi th a higher tendency of preferred orientation has closer bulk packing and talc with lower bulk density and higher surface area requires less peak force to break the tablet/die-wall adhesion.