BIOPHARMACEUTICAL STUDIES ON SOLID DISPERSIONS OF NALIDIXIC-ACID IN MODIFIED STARCHES

The objective of the study is to improve the dissolution rate and effi ciency and bioavailability. of nalidixic acid (NA) and to evaluate thr ee modified starches namely dextrin (D) beta-cyclodextrin (beta-CD) an d hydroxyethyl starch (HES) as carriers for solid dispersions. Solid d ispersions of NA in D, beta-CD and HES were prepared by common solvent method and the dispersions were evaluated by TLC, IR, DTA, X-ray diff raction, moisture absorption, dissolution rate and bioavailability stu dies. The three modified starches were found to be non-hygroscopic, no n-interacting carriers giving solid dispersions and effective in incre asing the dissolution rate efficiency and absorption, rate of NA.A mar ked reduction in the crystallinity and crystal size of NA in the dispe rsions was observed.