IDENTIFICATION OF A TOXR-ACTIVATED GENE, TAGE, THAT LIES WITHIN THE ACCESSORY COLONIZATION FACTOR GENE-CLUSTER OF VIBRIO-CHOLERAE-O395

Authors
KOVACH ME HUGHES KJ EVERISS KD PETERSON KM
Citation
Me. Kovach et al., IDENTIFICATION OF A TOXR-ACTIVATED GENE, TAGE, THAT LIES WITHIN THE ACCESSORY COLONIZATION FACTOR GENE-CLUSTER OF VIBRIO-CHOLERAE-O395, Gene, 148(1), 1994, pp. 91-95
Citations number
19
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
148
Issue
1
Year of publication
1994
Pages
91 - 95
Database
ISI
SICI code
0378-1119(1994)148:1<91:IOATGT>2.0.ZU;2-B
Abstract
The nucleotide (nt) sequence has been determined for a Vibrio cholerae ToxR-activated gene designated tagE that is located within a cluster of genes required for efficient intestinal colonization. The tagE gene encompasses 909 nt and is predicted to encode a 303-amino-acid (aa) p rotein with an estimated molecular mass of 34 468 Da. Computer-assiste d similarity searches revealed that TagE possesses aa sequence similar ity with Escherichia coli OrfU and staphylococcus simulans lysostaphin , two proteins that are involved in cell-wall biosynthesis and peptido glycan degradation, respectively. The role, if any, that TagE plays in the accessory colonization factor phenotype is currently under invest igation.