A STUDY ON THE ONCOGENES GLI, FOS, JUN AND MET IN HUMAN UTERINE LEIOMYOMAS

Authors
HAVEL G HELDIN NE WEDELL B JOHANSSON R MARK J
Citation
G. Havel et al., A STUDY ON THE ONCOGENES GLI, FOS, JUN AND MET IN HUMAN UTERINE LEIOMYOMAS, International journal of oncology, 5(5), 1994, pp. 1093-1097
Citations number
31
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
5
Issue
5
Year of publication
1994
Pages
1093 - 1097
Database
ISI
SICI code
1019-6439(1994)5:5<1093:ASOTOG>2.0.ZU;2-A
Abstract
122 human uterine leiomyomas, representing the main chromosomal aberra tions seen in these tumours, were analyzed by Southern blotting. Probe s for the four oncogenes, gli, fos, jun, and met, all localized in or close to the chromosomal breakpoints in leiomyomas, were used. In only one single leiomyoma, with a 7p+q- marker, was there evidence of rear rangement of one of the oncogenes, namely met.