REGULATION OF PML MESSENGER-RNA EXPRESSION IN HUMAN BREAST-CARCINOMA CELLS

We examined the mRNA expression profile of PML, a novel nuclear protei n recently characterized from acute promyelocytic leukemia (APL) blast cells, in a number of breast carcinoma cell lines. PML mRNA was found to be differentially expressed among the cell lines examined. A corre lation of borderline significance between PML mRNA expression and the proliferative capacity of the cell Lines was noted. Serum stimulation significantly elevated the PML mRNA levels in the T47D and MDA-MB-231 cells. These results would suggest that PML may function as a positive regulator of cellular proliferation in breast carcinoma cells.