MICRONUCLEATED ERYTHROCYTES AS AN ASSAY TO ASSESS ACTIONS BY PHYSICALAND CHEMICAL GENOTOXIC AGENTS IN CLARIAS-GARIEPINUS

Authors
BAHARI IB NOOR FM DAUD NM
Citation
Ib. Bahari et al., MICRONUCLEATED ERYTHROCYTES AS AN ASSAY TO ASSESS ACTIONS BY PHYSICALAND CHEMICAL GENOTOXIC AGENTS IN CLARIAS-GARIEPINUS, Mutation research. Section on environmental mutagenesis and related subjects, 313(1), 1994, pp. 1-5
Citations number
17
Categorie Soggetti
Genetics & Heredity","Environmental Sciences
Journal title
Mutation research. Section on environmental mutagenesis and related subjects → ACNP
ISSN journal
01651161
Volume
313
Issue
1
Year of publication
1994
Pages
1 - 5
Database
ISI
SICI code
0165-1161(1994)313:1<1:MEAAAT>2.0.ZU;2-Y
Abstract
An in vivo study on the effects of both physical (gamma-radiation) and chemical (mitomycin C) genotoxic agents was carried out with the catf ish species, Clarias gariepinus. The fish were either exposed to gamma -radiation at doses of 0-9 Gy or injected intraperitoneally with mitom ycin C at concentrations of 0-2 mg/kg. Micronucleated erythrocytes wer e sampled from 0 to 60 days post treatment. Data obtained showed a tim e-dependent response of the induction of micronucleated erythrocytes w ith both genotoxic agents. A linear dose-dependent increase was observ ed 2-4 days after treatment. These data show the importance of samplin g time in the micronucleus assay with Clarias gariepinus.