DNA BREAKAGE BY TANNIC-ACID AND CU(II) - GENERATION OF ACTIVE OXYGEN SPECIES AND BIOLOGICAL-ACTIVITY OF THE REACTION

Authors
BHAT R HADI SM
Citation
R. Bhat et Sm. Hadi, DNA BREAKAGE BY TANNIC-ACID AND CU(II) - GENERATION OF ACTIVE OXYGEN SPECIES AND BIOLOGICAL-ACTIVITY OF THE REACTION, Mutation research. Section on environmental mutagenesis and related subjects, 313(1), 1994, pp. 49-55
Citations number
17
Categorie Soggetti
Genetics & Heredity","Environmental Sciences
Journal title
Mutation research. Section on environmental mutagenesis and related subjects → ACNP
ISSN journal
01651161
Volume
313
Issue
1
Year of publication
1994
Pages
49 - 55
Database
ISI
SICI code
0165-1161(1994)313:1<49:DBBTAC>2.0.ZU;2-S
Abstract
Tannic acid was shown to reduce oxygen to superoxide anion. In the pre sence of Cu(II), the hydroxyl radical and hydrogen peroxide were forme d. Strand scission reaction was shown to account for the biological ac tivity of tannic acid as assayed by bacteriophage inactivation. The in activating activity occurs through the Fenton pathway for free radical production and subsequent DNA cleavage by these radicals.