SYNTHESES OF FUNCTIONALIZED INDIUM PORPHYRINS FOR MONOCLONAL-ANTIBODYLABELING

The syntheses and characterizations of five differently hydrosoluble m onosubstituted aryl porphyrins are reported. Their metallation with in dium-lll was achieved and provided tracers with strong specific activi ties. The covalent coupling between indium-lll porphyrins and BSA serv ed as a model reaction for the definition of the best experimental cou pling conditions; the transposition to the labeling of anti-CEA monocl onal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreact ivity.