NORMAL SEQUENCES OF MUSCARINIC ACETYLCHOLINE-RECEPTORS (M1 AND M2) INPATIENTS WITH ALZHEIMERS-DISEASE AND VASCULAR DEMENTIA

Authors
OHARA K KONDO N XIE D TANABE K YAMAMOTO T KOSAKA K MIYASATO K OHARA K
Citation
K. Ohara et al., NORMAL SEQUENCES OF MUSCARINIC ACETYLCHOLINE-RECEPTORS (M1 AND M2) INPATIENTS WITH ALZHEIMERS-DISEASE AND VASCULAR DEMENTIA, Neuroscience letters, 178(1), 1994, pp. 23-26
Citations number
35
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
178
Issue
1
Year of publication
1994
Pages
23 - 26
Database
ISI
SICI code
0304-3940(1994)178:1<23:NSOMA(>2.0.ZU;2-7
Abstract
The genes for muscarinic acetylcholine receptors, m1 and m2, were stud ied in autopsied brains from nine Alzheimer's disease. six vascular de mentia and three control. The genes were amplified by the polymerase c hain reaction and sequenced by the dideoxy method. Although one DNA po lymorphism was found in m1, the deduced amino acid sequences of the mu scarinic acetylcholine receptor were unchanged. The amino acid sequenc es of m1 and m2 in Alzheimer's disease and vascular dementia were inta ct.