BIDIRECTIONAL EFFECTS OF INTRATHECAL NMDA AND SUBSTANCE-P ON RAT DORSAL HORN NEURONAL RESPONSES

Authors
CHAPMAN V DICKENSON AH TJOLSEN A
Citation
V. Chapman et al., BIDIRECTIONAL EFFECTS OF INTRATHECAL NMDA AND SUBSTANCE-P ON RAT DORSAL HORN NEURONAL RESPONSES, Neuroscience letters, 178(1), 1994, pp. 90-94
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
178
Issue
1
Year of publication
1994
Pages
90 - 94
Database
ISI
SICI code
0304-3940(1994)178:1<90:BEOINA>2.0.ZU;2-9
Abstract
Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked res ponses, whereas 50 ng facilitated C-fibre and A delta-fibre evoked res ponses but not wind-up of convergent dorsal born neurones in the halot hane anaesthetized rat. Higher doses of NMDA and SP (10-500 ng) were w ithout effect. Co-administered SP (10 ng) with NMDA (5 ng) facilitated A delta-fibre evoked responses and wind-up. Excitatory amino acid and peptide interactions are discussed.