EFFECTS OF BIFEMELANE ON PARKINSONISM INDUCED BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN THE COMMON MARMOSET

Authors
NOMOTO M IRIFUNE M FUKUZAKI K FUKUDA T
Citation
M. Nomoto et al., EFFECTS OF BIFEMELANE ON PARKINSONISM INDUCED BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN THE COMMON MARMOSET, Neuroscience letters, 178(1), 1994, pp. 95-98
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
178
Issue
1
Year of publication
1994
Pages
95 - 98
Database
ISI
SICI code
0304-3940(1994)178:1<95:EOBOPI>2.0.ZU;2-E
Abstract
The effects of bifemelane on parkinsonism were shown in MPTP-treated c ommon marmosets. The administration of bifemelane increased locomotor activity in MPTP-treated marmosets but not in normal control marmosets . In a microdialysis study, extracellular levels of dopamine and its m etabolites increased following the administration of bifemelane. These results indicate that it is worth studying the effects of bifemelane hydrochloride on patients with Parkinson's disease.