LACTATE EFFLUX AND INTRACELLULAR PH DURING SEVERE HYPOXIA IN RAT CEREBRAL-CORTEX IN-VITRO STUDIED BY NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

Authors
PIRTTILA TRM KAUPPINEN RA
Citation
Trm. Pirttila et Ra. Kauppinen, LACTATE EFFLUX AND INTRACELLULAR PH DURING SEVERE HYPOXIA IN RAT CEREBRAL-CORTEX IN-VITRO STUDIED BY NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY, Neuroscience letters, 178(1), 1994, pp. 111-114
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
178
Issue
1
Year of publication
1994
Pages
111 - 114
Database
ISI
SICI code
0304-3940(1994)178:1<111:LEAIPD>2.0.ZU;2-F
Abstract
Intracellular pH (pH(i)) and lactate were monitored in a superfused br ain slice preparation using NMR spectroscopy in order to study the rol e of lactate washout in maintenance of pH(i) during hypoxia. Data are consistence with a functioning lactate-H+ cotransport in the energetic ally intact cerebral cortex. This pathway is not, however, linked to r egulation of pH, during energy failure with external pH of 6.8 and thu s appears not to have physiological impact in H+ homeostasis during ce rebral hypoxia.