ON THE MECHANISM OF ANTIEPILEPTIC PEPTIDES APPEARANCE IN THE CEREBROSPINAL-FLUID

Authors
SHANDRA AA GODLEVSKY LS MAZARATI AM PANENKO AV TKACHENKO IV CHIRKOV YP
Citation
Aa. Shandra et al., ON THE MECHANISM OF ANTIEPILEPTIC PEPTIDES APPEARANCE IN THE CEREBROSPINAL-FLUID, Brain research bulletin, 35(4), 1994, pp. 285-287
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research bulletin → ACNP
ISSN journal
03619230
Volume
35
Issue
4
Year of publication
1994
Pages
285 - 287
Database
ISI
SICI code
0361-9230(1994)35:4<285:OTMOAP>2.0.ZU;2-S
Abstract
Intraventricular injection of cerebrospinal fluid obtained from cats w ith electroshock seizures resulted in suppression of generalized picro toxin-induced seizures in rats. Antiepileptic action of cerebrospinal fluid was abolished by partial bilateral midbrain destruction that inc luded the region of colliculi superii. Electrical stimulation of cereb ellum in cats with such destructions caused the appearance of a pronas e-sensitive antiepileptic substances in cerebrospinal fluid.