AUTORADIOGRAPHIC CHARACTERIZATION OF I-125 NEUROTENSIN BINDING-SITES IN HUMAN ENTORHINAL CORTEX

The laminar and rostro-caudal distribution of I-125-neurotensin bindin g sites is described in human entorhinal cortex using quantitative aut oradiography. Specific binding was most prominent over the cell cluste rs of layer II of the entorhinal cortex throughout its rostro-caudal e xtent. Dense binding was also observed in the adjacent presubiculum an d cortical amygdaloid transition area, whereas minimal binding was det ected in the hippocampus and dentate gyrus. I-125-Neurotensin may serv e as a selective probe for neurotensin receptor alterations and layer II-specific cytoarchitectural disturbances in the entorhinal cortex in neuropsychiatric diseases associated with abnormalities of the mesial temporal lobe.