CONJUGATION REACTIONS OF CYCLODEPSIPEPTIDE TO GLUTATHIONYL ADDUCTS BYDIRECT IN-BEAM SYNTHESIS UNDER NEGATIVE-ION FAST-ATOM-BOMBARDMENT CONDITIONS

Authors
LOUTELIER C CHERTON JC LANGE C
Citation
C. Loutelier et al., CONJUGATION REACTIONS OF CYCLODEPSIPEPTIDE TO GLUTATHIONYL ADDUCTS BYDIRECT IN-BEAM SYNTHESIS UNDER NEGATIVE-ION FAST-ATOM-BOMBARDMENT CONDITIONS, Rapid communications in mass spectrometry, 8(10), 1994, pp. 844-848
Citations number
12
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
8
Issue
10
Year of publication
1994
Pages
844 - 848
Database
ISI
SICI code
0951-4198(1994)8:10<844:CROCTG>2.0.ZU;2-K
Abstract
The conjugation products of E-destruxin (cyclodepsipeptide) with gluta thione have been identified by fast-atom bombardment mass spectrometry . Appropriate conditions were developed for cyclodepsipeptide substrat e, which enabled the direct, dynamic mass spectra analysis of spontane ous as well as glutathione-s-transferase catalyzed conjugation reactio ns. Application to the most active cyclopeptide in the series of destr uxins yielded glutathionyl adduct.