F. Hajos et al., MATURATION OF THE GFAP-IMMUNOPOSITIVE GLIAL NETWORK IS DELAYED IN THEOLFACTORY BULBS OF RATS SUBJECTED TO EARLY, LOW-DOSE X-IRRADIATION, Glia, 12(2), 1994, pp. 144-150
Young rats were subjected to low-level, repeated doses of x-irradiatio
n from a Co-60 source and examined for the presence and arrangement of
their GFAP-immunopositive system at the light and electron microscopi
c levels. In 2-week-old control rats, labelled cells were already dist
ributed homogeneously throughout the bulb, while in the experimental a
nimals, a (newborn- and early postnatal-type) radial arrangement of im
munoreactive fibres continued to persist even until the end of the fou
rth postnatal week. This delay in the maturation of the GFAP-immunopos
itive glial system may contribute to the hindered development of the b
ulbar neurones, neuronal connections, and field potentials, as found i
n earlier studies. (C) 1994 Wiley-Liss, Inc.