ENCEPHALOMYOCARDITIS (EMC) VIRUS-INDUCED TESTICULAR LESION IN BALB C MICE/

Characteristics of encephalomyocarditis (EMC) virus-induced testicular lesions were investigated in 4- and 8-week-old BALB/c male mice after intraperitoneal (i.p.) and intratesticular (left) (i.t.) inoculation of the D variant of EMC virus (EMC-D). Apart from variation in severit y and incidence, the histopathological nature of the resultant testicu lar lesion was similar in all infected mice, and was characterized by degeneration and necrosis of germinal cells and spermatogonia with inf lammatory infiltration. Almost all the inoculated left testes of the i .t. group developed marked lesions. In general, the virus titre in the testis and incidence of testicular lesions were higher in 4-week-old mice than in 8-week-old mice. In addition, testicular lesions develope d earlier and with a higher incidence in the PBS-inoculated right test is of the i.t. group than in either testis of the i.p. group of the sa me age.