FORMATION OF LAMINA-SPECIFIC CORTICAL AFFERENT CONNECTIONS STUDIED INORGANOTYPIC COCULTURES

Authors
YAMAMOTO N YAMADA K KUROTANI T HIGASHI S SUGIHARA H TOYAMA K
Citation
N. Yamamoto et al., FORMATION OF LAMINA-SPECIFIC CORTICAL AFFERENT CONNECTIONS STUDIED INORGANOTYPIC COCULTURES, Biomedical research, 15, 1994, pp. 119-121
Citations number
20
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Biomedical research → ACNP
ISSN journal
03886107
Volume
15
Year of publication
1994
Supplement
1
Pages
119 - 121
Database
ISI
SICI code
0388-6107(1994)15:<119:FOLCAC>2.0.ZU;2-Y
Abstract
Laminar organization is one of the basic structures in the cortical ci rcuitry. Our studies using organotypic cocultures have demonstrated th at cortical afferent connections are established in vitro with essenti ally the same laminar specificity as those found in the adult neocorte x. A study of growing axons further suggests the existence of specific cues which are responsible for the formation of lamina-specific conne ctions.