The acronym TORCH has served to increase awareness of congenital infec
tions; however, this collective term suggests that the clinical manife
stations of congenital infections are not distinguishable by pathogen.
Although some clinical features may be common to several of these inf
ections, a Congenital infection caused by one pathogen generally can b
e distinguished from infection caused by another pathogen on a clinica
l basis. Pediatricians need to be aware of the prominent features of e
ach congenital infection rather than to consider them collectively. Th
is article focuses on the prominent features of the more common congen
ital infections, suggests a specific diagnostic approach, and reviews
the available therapeutic strategies.