The evolution of the diagnosis, etiology, management, and prognosis of
neonatal seizures over the past two decades is reviewed. Seizures in
the neonate are unique and require special classification. They result
from acquired or congenital abnormalities of the central nervous syst
em. Clustering of prognostic parameters, including seizure characteris
tics, perinatal factors, neurologic signs, cause, and neuroimaging and
electroencephalographic abnormalities, allows neonatal seizures to be
viewed as clinical syndromes with predictable outcomes.