The general opinion that treadmill exercise elicits circulatory reserv
e more than bicycle exercise derives from studies conducted in normal
subjects or subjects with coronary artery disease. To investigate if t
his also occurs in patients with chronic heart failure (CHF), 40 patie
nts (mean ejection fraction: 26 +/- 9 percent) pith normal pulmonary f
unction underwent in random order both treadmill (Naughton modified pr
otocol, holding on handrails permitted) and bicycle (10 W/min) maximal
exercise over a 1-week period. Peak oxygen uptake (19.6 +/- 5.3 vs 17
.6 +/- 5.1 ml/min/kg, p<0.0001), ventilatory threshold (14.4 +/- 4.7 v
s 12.0 +/- 3.5 ml/min/kg, p<0.0001), and minute ventilation (59 +/- 18
vs 55 +/- 15 L/min, p<0.05) were greater on treadmill than on bicycle
. Heart rate, systolic blood pressure, breathing rate, respiratory exc
hange ratio, perceived exertion scale, and lactate were identical. The
coefficient of the correlation between oxygen uptake and time was gre
ater with bicycle than with treadmill (r=0.97 +/- 0.04 vs 0.90 +/- 0.0
7, p<0.001). Thus, treadmill exercise is more suitable for determining
peak oxygen uptake in patients with CHF. However, the increase in oxy
gen uptake is more regular with bicycle exercise.