From 1991 until 1993 we used fluconazole in 56 cases of oral candidosi
s which could not be managed by local therapy only. In seven cases the
re was no clinical improvement. A mycological cure was seen in 44 case
s. In cases of oral candidosis which do not respond to local therapy f
luconazole has proven a success especially in the follow up of patient
s with oral cancer and in cases of oral precancerous lesions with myco
tic colonization.