POTENTIOMETRIC STUDY OF INTERACTION OF GLUTARIMIDE, N-PHENYLACETYL-L-GLUTAMINE, AND N-ACETYL-L-GLUTAMINE WITH A SERIES OF METAL-IONS

The interaction of glutarimide, N-phenylacetyl-L-glutamine, and N-acet yl-L-glutamine with Cu(II), Ni(II), Co(II), Zn(II), Mn(II), Cd(II), Pb (II), Mg(II), and Ca(II) ions has been investigated by a potentiometri c method. It is concluded that N-phenylacetyl-L-glutamine and N-acetyl -L-glutamine are unable to form stable complexes with the above metal ions in solution on varying the pH values, which is important in view of the pharmacological application of these compounds. Glutarimide for ms complexes with Cu(II), Zn(II), Co(II), and Ni(II) ions. The stabili ty constants of the 1 : 1 and 1 : 2 metal-glutarimide complexes have b een determined at 45-degrees-C and 0.10 mol dm-3 (KNO3) ionic strength .