AMPHIPHILIC VINYL-POLYMERS EFFECTIVELY PROLONG LIPOSOME CIRCULATION TIME IN-VIVO

Authors
TORCHILIN VP SHTILMAN MI TRUBETSKOY VS WHITEMAN K MILSTEIN AM
Citation
Vp. Torchilin et al., AMPHIPHILIC VINYL-POLYMERS EFFECTIVELY PROLONG LIPOSOME CIRCULATION TIME IN-VIVO, Biochimica et biophysica acta. Biomembranes, 1195(1), 1994, pp. 181-184
Citations number
12
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1195
Issue
1
Year of publication
1994
Pages
181 - 184
Database
ISI
SICI code
0005-2736(1994)1195:1<181:AVEPLC>2.0.ZU;2-V
Abstract
Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidon e), single terminus-modified with long-chain fatty acyl groups, are ab le to incorporate into the liposomal membrane, and similar to poly(eth ylene glycol) prolong liposome circulation in vivo and decrease liposo me accumulation in the liver. Protective efficacy of modified polymers increases with the increase in the length of acyl moiety and decrease s for higher molecular weight polymers. The data on amphiphilic polyme r-modified liposome biodistribution are presented.