CDNA SEQUENCES OF SCHISTOSOMA-JAPONICUM CODING FOR 2 CATHEPSIN-B-LIKEPROTEINS AND SJ32

Authors
MERCKELBACH A HASSE S DELL R ESCHLBECK A RUPPEL A
Citation
A. Merckelbach et al., CDNA SEQUENCES OF SCHISTOSOMA-JAPONICUM CODING FOR 2 CATHEPSIN-B-LIKEPROTEINS AND SJ32, Tropical medicine and parasitology, 45(3), 1994, pp. 193-198
Citations number
35
Categorie Soggetti
Parasitiology,"Tropical Medicine
Journal title
Tropical medicine and parasitology → ACNP
ISSN journal
01772392
Volume
45
Issue
3
Year of publication
1994
Pages
193 - 198
Database
ISI
SICI code
0177-2392(1994)45:3<193:CSOSCF>2.0.ZU;2-5
Abstract
Sequences of three cDNAs of Schistosoma japonicum are presented. Two o f them code for the antigens Sj32 (hemoglobinase) and cathepsin B. The third clone represents a mutant derivative of the cathepsin B gene. T he DNA and amino acid sequences are compared to their homologues from S. mansoni. The mutant cathepsin B, in which the Cys(29) in the active center is replaced by Ser, is discussed with respect to a possible fu nction.