In the classical Pavlovian conditioning paradigm; a stimulus that unco
nditionally elicits a physiological response is repeatedly paired with
a neutral stimulus that does not elicit that same response. Eventuall
y, the neutral stimulus becomes a conditioned stimulus in that it elic
its the physiological response in the absence of an unconditioned stim
ulus. Here we summarize experiments in which Pavlovian conditioning ha
s revealed an intimate relationship between the central nervous system
and the immune system.