PHARMACOKINETICS AND ANTIVIRAL ACTIVITY OF A NOVEL ISONUCLEOSIDE, BMS-181165, AGAINST SIMIAN VARICELLA VIRUS-INFECTION IN AFRICAN-GREEN MONKEYS

Authors
SOIKE KF HUANG JL RUSSELL JW WHITEROCK VJ SUNDEEN JE STRATTON LW CLARK JM
Citation
Kf. Soike et al., PHARMACOKINETICS AND ANTIVIRAL ACTIVITY OF A NOVEL ISONUCLEOSIDE, BMS-181165, AGAINST SIMIAN VARICELLA VIRUS-INFECTION IN AFRICAN-GREEN MONKEYS, Antiviral research, 23(3-4), 1994, pp. 219-224
Citations number
9
Categorie Soggetti
Virology
Journal title
Antiviral research → ACNP
ISSN journal
01663542
Volume
23
Issue
3-4
Year of publication
1994
Pages
219 - 224
Database
ISI
SICI code
0166-3542(1994)23:3-4<219:PAAAOA>2.0.ZU;2-7
Abstract
A novel nucleoside analog BMS-181165 with potent activity against vari cella-zoster virus was tested for efficacy in a simian varicella virus infection in African green monkeys. BMS-181165 was effective in preve nting the development of a rash, decreasing the development of viremia and preventing death in infected monkeys when administered orally at 4, 16 or 64 mg/kg/day. The compound is well orally absorbed in monkeys , between 44 to 50% oral bioavailability, and may prove of value in th erapy of varicella-zoster infections in humans.