STUDY OF CYTOKINE SYSTEM IN PATIENTS WITH KAPOSIS-SARCOMA

Immunity status of patients with the ''classical'' Kaposi's sarcoma wa s carried out with consideration for immune response mediators (IL-1, TNF) and interferon status. The examined parameters were shifted both in the T and B immunity systems. Immunity activity in Kaposi's sarcoma was found related to activation of a large group of cells producing I L-1, TNF, and other cytokins. Activity of mediators (IL-1, TNF) was de pressed, interferon production reduced. All these changes lead to immu nity system imbalance, the depth of this imbalance correlating with th e clinical picture of the disease. Study of immunity status with consi deration for cytokins and their interactions with cells gives us new d ata on the pathogenesis of Kaposi's sarcoma and permits regarding many problems from new viewpoints.