I-123-N-(di-ethylamino-2-ethyl) 4 iodobenzamide (I-BZA) has been put f
orward by the Clermont-Ferrand INSERM U71 group (France) as a tracer f
or malignant melanoma. We report on the clinical results obtained in 5
6 studies performed on 48 patients. Whole body scans along with spot v
iews were obtained after injection of 185 MBq of I-BZA. The scans were
read by three independent observers and correlated to the clinical fi
ndings and the other imaging modalities available, taking into account
all lesions larger than 1 cm. Patients were classified into two group
s on the basis of a post-treatment survey of patients: group I, in com
plete remission (24 scans); group II: documented metastases (32 scans)
. In group 1, 21 studies were truly negative. However, three studies s
howed positive results. Only one turned out to be a false positive (sp
ecificity 95%), the other two revealed unknown lesions and modified th
e patients' management. In group II, 73% of the known metastases were
detected with higher sensitivities (>80%) for eye and orbit, lung and
abdomen. One false positive was reported and four new lesions were det
ected. I-BZA scintigraphy has the same sensitivity as immunoscintigrap
hy with higher specificity and without the risk of xenoimmunization. I
t is a useful tool for staging malignant melanoma which can improve pa
tient management.