Vv. Samukov et al., 2-(4-NITROPHENYL)SULFONYLETHOXYCARBONYL (NSC) GROUP AS A BASE-LABILE ALPHA-AMINO PROTECTION FOR SOLID-PHASE PEPTIDE-SYNTHESIS, Tetrahedron letters, 35(42), 1994, pp. 7821-7824
Base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc) group is pro
posed for a temporary alpha-amino protection in the solid phase peptid
e synthesis. Nsc-Group is cleaved by organic bases in aprotic solvents
under mild conditions similar to that used for Fmoc-group. Several N
alpha-Nsc amino acids are prepared and used in the solid phase synthes
is of the fragment 307-318 of S-protein from bovine eye retina.