2-(4-NITROPHENYL)SULFONYLETHOXYCARBONYL (NSC) GROUP AS A BASE-LABILE ALPHA-AMINO PROTECTION FOR SOLID-PHASE PEPTIDE-SYNTHESIS

Authors
SAMUKOV VV SABIROV AN POZDNYAKOV PI
Citation
Vv. Samukov et al., 2-(4-NITROPHENYL)SULFONYLETHOXYCARBONYL (NSC) GROUP AS A BASE-LABILE ALPHA-AMINO PROTECTION FOR SOLID-PHASE PEPTIDE-SYNTHESIS, Tetrahedron letters, 35(42), 1994, pp. 7821-7824
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
42
Year of publication
1994
Pages
7821 - 7824
Database
ISI
SICI code
0040-4039(1994)35:42<7821:2(GAAB>2.0.ZU;2-H
Abstract
Base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc) group is pro posed for a temporary alpha-amino protection in the solid phase peptid e synthesis. Nsc-Group is cleaved by organic bases in aprotic solvents under mild conditions similar to that used for Fmoc-group. Several N alpha-Nsc amino acids are prepared and used in the solid phase synthes is of the fragment 307-318 of S-protein from bovine eye retina.