Background Pontine infarctions may produce combined motor, sensory, ce
rebellar, and cranial nerve dysfunction. Midline sensory complaints an
d facial pain are uncommon. Case Descriptions Three patients are descr
ibed with hypoesthesia and numbness of the midline facial area associa
ted with dysarthria and contralateral hemiparesis due to pontine strok
es. MRI demonstrated isolated ipsilateral ischemic infarctions of the
ventral pens. Conclusions Pontine infarctions can produce diverse sens
ory features. Ipsilateral midfacial sensory defect has been rarely rep
orted. The clinicoanatomic basis for the ipsilateral midfacial sensory
defect described is unknown. Involvement of the dorsal trigeminothala
mic tract or fiber tracts related to central regions of the face, loca
ted in the medial part of the midbrain, could help to explain these da
ta. The symptoms could be due to direct damage or to edema resulting f
rom the infarct. In some patients, midfacial sensory complaints, parti
cularly of the ala nasi, could be an early sign of major pontine defic
its and may be important to determine appropriate treatment.