PARACETAMOL AND CAFFEINE SIMULTANEOUS DET ERMINATION BY DERIVED - UV ABSORPTION SPECTROPHOTOMETRY - A COMPARATIVE-STUDY OF 2 DERIVATION METHODS

Authors
SURMEIAN M GEORGESCU D COSOFRET VV
Citation
M. Surmeian et al., PARACETAMOL AND CAFFEINE SIMULTANEOUS DET ERMINATION BY DERIVED - UV ABSORPTION SPECTROPHOTOMETRY - A COMPARATIVE-STUDY OF 2 DERIVATION METHODS, Revista de chimie, 45(9), 1994, pp. 823-826
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Revista de chimie → ACNP
ISSN journal
00347752
Volume
45
Issue
9
Year of publication
1994
Pages
823 - 826
Database
ISI
SICI code
0034-7752(1994)45:9<823:PACSDE>2.0.ZU;2-3
Abstract
The UV-derivative spectrophotometric method was used for the simultane ous determination of paracetamol (PA) and caffeine (CAF). The first an d second derivative spectra were obtained with a TURBO-PASCAL computer program and SPECORD M-42 (Carl-Zeiss Jena) respectively. The quantita tive determination of both drugs was made using the ''zero-crossing'' technique, in the range of concentration: 10-40 mug/ml for PA and 1.0- 3.0 mug/ml for CAF. The method was applied for the simultaneous determ ination of the two drugs from CODAMIN P-tablets.