(+ -)-GELLIUSINE-A AND (+/-)-GELLIUSINE-B, 2 DIASTEREOMERIC BROMINATED TRIS-INDOLE ALKALOIDS FROM A DEEP-WATER NEW CALEDONIAN MARINE SPONGE(GELLIUS OR ORINA SP)/

Authors
BIFULCO G BRUNO I MINALE L RICCIO R CALIGNANO A DEBITUS C
Citation
G. Bifulco et al., (+ -)-GELLIUSINE-A AND (+/-)-GELLIUSINE-B, 2 DIASTEREOMERIC BROMINATED TRIS-INDOLE ALKALOIDS FROM A DEEP-WATER NEW CALEDONIAN MARINE SPONGE(GELLIUS OR ORINA SP)/, Journal of natural products, 57(9), 1994, pp. 1294-1299
Citations number
22
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
9
Year of publication
1994
Pages
1294 - 1299
Database
ISI
SICI code
0163-3864(1994)57:9<1294:(-A(2D>2.0.ZU;2-5
Abstract
Two new diastereomeric brominated tris-indole alkaloids occurring as e nantiomeric pairs, (+/-)-gelliusines A [1] and B [2], have been isolat ed from a deep water New Caledonian sponge (Gellius or Orina sp.), who se crude extract exhibited cytotoxicity against KB cells. Their struct ures were elucidated by spectroscopic methods including one- and two-d imensional nmr spectroscopy. The major compound, (+/-) gelliusine A [1 ], which showed very weak cytotoxicity, proved to be active at the ser otonin receptor.