BINDING OF QUINOLIZIDINE ALKALOIDS TO NICOTINIC AND MUSCARINIC ACETYLCHOLINE-RECEPTORS

Authors
SCHMELLER T SAUERWEIN M SPORER F WINK M MULLER WE
Citation
T. Schmeller et al., BINDING OF QUINOLIZIDINE ALKALOIDS TO NICOTINIC AND MUSCARINIC ACETYLCHOLINE-RECEPTORS, Journal of natural products, 57(9), 1994, pp. 1316-1319
Citations number
13
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
9
Year of publication
1994
Pages
1316 - 1319
Database
ISI
SICI code
0163-3864(1994)57:9<1316:BOQATN>2.0.ZU;2-I
Abstract
Fourteen quinolizidine alkaloids, isolated from Lupinus albus, L. muta bilis, and Anagyris foetida, were analyzed for their affinity for nico tinic and/or muscarinic acetylcholine receptors. Of the compounds test ed, the alpha-pyridones, N-methylcytisine and cytisine, showed the hig hest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.