UNSTABLE ANGINA - RELATION OF DATA OBTAIN ED UPON ADMISSION TO OUTCOME OF HOSPITALIZATION - VALUE OF PARAMETERS OF HEMOSTASIS

The aim of the study was to assess value for prognosis of inhospital m yocardial infarction and death of data obtained upon admission to coro nary care unit of 94 patients with acute unstable angina. These patien ts were included into double blind placebo controlled comparison of ef ficacy of aspirin and intravenous heparin. At multifactorial stepwise discriminant analysis the following 6 parameters were independently re lated to death and development of myocardial infarction: long term use of antihypertensive drugs before hospitalization, ST segment elevatio ns on admission ECG, age, duration of unstable angina (in days), hepar in use by the ambulance staff in prehospital treatment, white blood ce ll count. In a subgroup of patients in whom parameters of hemostasis w ere determined antithrombin III level entered the list of predictors o f major cardiac events while levels of fibrinogen, protein C, activity of tissue plasminogen activator inhibitor, cholesterol and lipoprotei ns were not related to outcome of hospitalization.