APOLIPOPROTEIN-E IN PATIENTS WITH ISCHEMI C-HEART-DISEASE

Contents of lipoprotein E and parameters of lipoprotein metabolism wer e determined in serum from 78 patients with ischemic heart disease and different variants of lipid metabolism disturbances. Twenty patients had moderately elevated cholesterol levels (5.2 - 6.2 mmol/l) and norm al triglycerides (2.3 mmol/l or less), and 58 patients had pronounced hyperlipoproteinemia which in 40 patients could be classified as Fredr ickson type 11a, in 14 - type 11b and in 4 - type IV hyperliproprotein emia. In patients with pronounced disturbances of lipid metabolism (wi th different types of hyperlipoproteinemias) serum apo-E levels were h igher than in patients with moderate hypercholesterolemia. No signific ant correlations were found between serum apoprotein E levels and cont ents of lipids both in serum and in separate classes of lipoproteins.