EFFECTS OF GRADED HYPERCAPNIC HYPOXIA ON PARAMETERS OF CARDIORESPIRATORY SYSTEM AND PHYSICAL WORKING CAPACITY OF PATIENTS WITH ISCHEMIC-HEART-DISEASE

Test with graded hypercapnic hypoxia was performed in 35 patients with ischemic heart disease and 15 healthy persons by closed circuit rebre athing method. The state of central and cerebral hemodynamics, paramet ers of pulmonary ventilation, blood gases and acid-based balance were studied. Both in healthy persons and in patients with ischemic heart d isease hypercapnic hypoxia led to increase in cardiac output while vol ume velocity of cerebral blood flow remained unchanged in patients but rose significantly in healthy persons. At equal contents of oxygen in inhaled air relative lack of development of arterial hypoxemia was no ted in patients compared to healthy persons. Course intervention by hy percapnic hypoxia resulted in increased physical working capacity of p atients with angina pectoris.