A six-month-old colt was presented for evaluation of chronic joint dis
tention in the tarsocrural joint. Routine arthroscopy and castration w
ere performed on the colt. During recovery, the colt showed signs of d
ifficulty to rise. Differential diagnoses were myopathy, peripheral ne
uropathy, fracture, and a central neuropathy. The colt was treated wit
h intravenous fluid and anti-inflammatory agents. A complete neurologi
cal exam was performed and deficits in the rear consistent with upperm
otor neuron damage. The owner elected humane destruction of the colt a
nd a post-mortem exam was performed. A diagnosis of hemorrhagic myelop
athy (hematomyelia) was confirmed. Post anesthetic and surgical hemorr
hagic myelopathy (hematomyelia) is a rarely encountered neuropathologi
cal condition associated with general anesthesia and surgery in the ho
rse. The infrequent occurrence limits opportunities to study contribut
ing factors associated with this complication other than on a retrospe
ctive basis. This report details clinical observations, anesthetic pro
tocol, post anesthetic evaluation attempting to provide physiological
suggestions that result in the neurological complication. Previously r
eported cases in the literature are evaluated and compared to this cas
e, documenting common factors present in all reports.