A 28-year-old woman developed hirsutism, facial edema and clitoromegal
y after self-injection of long-acting synthetic androgens. The symptom
s were ameliorated by administration of flutamide with a combination o
ral contraceptive. Flutamide appears to be useful in preventing sequel
ae of acute androgen excess in women and may be a rational therapy for
chronic treatment of androgen excess in women.