CLINICAL COURSE OF IDIOPATHIC ANAPHYLAXIS

Background: Only a few groups have reported on idiopathic anaphylaxis. We analyzed our experience with idiopathic anaphylaxis, especially in regards to prognosis. Methods: Thirty-seven patients with the diagnos is of idiopathic anaphylaxis were retrospectively identified by a medi cal records search from 1989-1992. Thirty-five patients were evaluable and a telephone questionnaire was conducted to determine the current treatment and course of their idiopathic anaphylaxis since their initi al evaluation. Results: Patient ages ranged from 26 to 71 years (mean 48), 72% were women, and 43% were atopic. Frequent episodes of idiopat hic anaphylaxis (>5/year) occurred in 31%. At follow-up (mean 2.5 year s), 21 patients (60%) had resolution of idiopathic anaphylaxis, and th e frequency of anaphylaxis was decreased in nine, increased in two, an d the same in three patients. Only three patients were still having fr equent episodes and two required chronic glucocorticoids. Patients wit h frequent idiopathic anaphylaxis treated with only antihistamines and adrenergics underwent remission or improvement as frequently as those treated with chronic glucocorticoids. Conclusions: These results are similar to other reports of idiopathic anaphylaxis and indicate a gene rally favorable prognosis. Some patients with frequent idiopathic anap hylaxis improved without the need for glucocorticoids. Well controlled studies may be required to analyze the role of glucocorticoids in thi s disease.