FAMILIAL ANAPLASTIC EPENDYMOMA - EVIDENCE OF LOSS OF CHROMOSOME-22 INTUMOR-CELLS

A family with anaplastic ependymomas, histologically verified in three cases and neuroradiologically suggested in a fourth, is presented. Tw o healthy brothers both had two affected sons. Ah four male patients w ere younger than 5 years at the time of diagnosis. Two boys died befor e the age of 3 years. Genotype analysis (with polymorphic DNA markers for chromosome 22 and interphase cytogenetic analysis) of one of the t umours showed a subpopulation of tumour cells with monosomy of (part o f) chromosome 22. Non-neoplastic cells of this patient showed a normal karyotype. These findings give further evidence for the role of a tum our suppressor gene on chromesome 22 in the pathogenesis of familial e pendymal tumours.