BINDING OF THE GALACTOSE-SPECIFIC PSEUDOMONAS-AERUGINOSA LECTIN, PA-I, TO GLYCOSPHINGOLIPIDS AND OTHER GLYCOCONJUGATES

Authors
LANNE B CIOPRAGA J BERGSTROM J MOTAS C KARLSSON KA
Citation
B. Lanne et al., BINDING OF THE GALACTOSE-SPECIFIC PSEUDOMONAS-AERUGINOSA LECTIN, PA-I, TO GLYCOSPHINGOLIPIDS AND OTHER GLYCOCONJUGATES, Glycoconjugate journal, 11(4), 1994, pp. 292-298
Citations number
44
Categorie Soggetti
Biology
Journal title
Glycoconjugate journal → ACNP
ISSN journal
02820080
Volume
11
Issue
4
Year of publication
1994
Pages
292 - 298
Database
ISI
SICI code
0282-0080(1994)11:4<292:BOTGPL>2.0.ZU;2-I
Abstract
The carbohydrate-binding specificity of Pseudomonas aeruginosa lectin I (PA-I) in iodinated or biotinylated form was studied. A large number of glycosphingolipids, as well as some glycoproteins and neoglycoprot eins were used as ligands. Also, inhibition by free saccharides of PA- I binding to glycosphingolipids was tested. It was found that the lect in binds most strongly to terminal and nonsubstituted Gal alpha 3Gal- or Gal alpha 4Gal-structures.