ENDOTHELIAL-CELL PROLIFERATION-ASSOCIATED WITH LESIONS OF MURINE SYSTEMIC CANDIDIASIS

Neovascularization is associated with tumor growth and some inflammato ry diseases but has not been reported to be induced by infectious agen ts. In a mouse model of systemic Candida albicans infection, extensive endothelial cell proliferation was seen in the periphery of brain abs cesses and in the areas of fungal pyelonephritis in the kidney. This f inding is important for an understanding of the pathogenesis of fungal infections and may contribute to an analysis of the mechanisms of ang iogenesis.