HYPOGLYCEMIA AND HYPERINSULINEMIA IN RODENT MODELS OF SEVERE MALARIA INFECTION

Authors
ELASED K PLAYFAIR JHL
Citation
K. Elased et Jhl. Playfair, HYPOGLYCEMIA AND HYPERINSULINEMIA IN RODENT MODELS OF SEVERE MALARIA INFECTION, Infection and immunity, 62(11), 1994, pp. 5157-5160
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
11
Year of publication
1994
Pages
5157 - 5160
Database
ISI
SICI code
0019-9567(1994)62:11<5157:HAHIRM>2.0.ZU;2-Q
Abstract
Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in ass ociation with hyperinsulinemia. Supernatants of lethal P. yoelii incub ated overnight induced hypoglycemia and hyperinsulinemia in normal mic e. In murine malaria, hypoglycemia may be largely secondary to increas ed insulin secretion.