STRAINS OF MYCOBACTERIUM-TUBERCULOSIS DIFFER IN SUSCEPTIBILITY TO REACTIVE NITROGEN INTERMEDIATES IN-VITRO

Authors
OBRIEN L CARMICHAEL J LOWRIE DB ANDREW PW
Citation
L. Obrien et al., STRAINS OF MYCOBACTERIUM-TUBERCULOSIS DIFFER IN SUSCEPTIBILITY TO REACTIVE NITROGEN INTERMEDIATES IN-VITRO, Infection and immunity, 62(11), 1994, pp. 5187-5190
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
11
Year of publication
1994
Pages
5187 - 5190
Database
ISI
SICI code
0019-9567(1994)62:11<5187:SOMDIS>2.0.ZU;2-2
Abstract
The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in vitro resist ance of mycobacteria to reactive nitrogen intermediates, generated at an acidic pH, was found to have a significant (P < 0.05) positive corr elation to the virulence of strains in guinea pigs.