We report a patient, PP, with semantic dementia who was studied longit
udinally over two years. During this period she showed a progressive a
nd profound loss of semantic memory affecting factual knowledge, vocab
ulary, and object knowledge via all sensory modalities. In the face of
this near total dissolution of semantic memory, we have addressed the
issue of the fate of other cognitive processes. Our findings suggest
that nonverbal problem solving, auditory verbal and spatial short-term
memory, the high-level visuoperceptual abilities involved in object c
onstancy, and some basic syntactic processes may operate independently
of semantic memory and are therefore independent cognitive modules. I
n contrast, the integrity of both the phonological representations of
words used to produce speech and the representations (or structural de
scriptions) used to recognise familiar objects appear ultimately to de
pend on semantic memory.