THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF A PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM ARABIDOPSIS-THALIANA

The nucleotide sequence of a cDNA clone from Arabidopsis thaliana ecot ype Columbia was determined, and the corresponding amino acid sequence deduced. The predicted sequence is highly homologous to those of memb ers of the cyclophilin A-family of peptidyl-prolyl cis-trans isomerase s. The tryptophan residue necessary for interaction with cyclosporin A is located at approximately the same position in the plant sequence a s it is in mammalian sequences. The carboxy-terminus of the plant prol yl isomerase sequence contains a cryptic prenylation motif.